Wing George North is set to miss Wales' autumn Tests because of a knee injury.
The 25-year-old was injured during Northampton's 57-13 home defeat by Saracens in the European Champions Cup on Sunday and could be out for six to eight weeks.
Ospreys scrum-half Rhys Webb and fellow Osprey Dan Baker, a back-rower, are also doubts.
Baker left the fray against Clermont Auvergne on a stretcher and Webb was also forced off.
Wales coach Warren Gatland is due to name his squad for the four autumn Tests on Tuesday, 24 October.
His side face the Wallabies on 11 November, Georgia on 18 November, the All Blacks on 25 November and the Springboks on 2 December.
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North's injury was confirmed by a scan on Tuesday after he had to be helped off at Franklin's Gardens at the weekend.
After their defeat by Clermont, Ospreys coach Steve Tandy said: "Dan Baker had a bad one. We will have to wait 24 to 48 hours until we will know more."
However, he acknowledged the replacement of scrum-half Webb was more precautionary.
"I think Rhys was just cramping up," he added.
"He's been banged up after not playing too much recently so it was probably just fatigue.
"Hopefully it's not too serious."
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