Manchester United make six changes from the side who beat Saint-Etienne in France on Wednesday.
David de Gea, Antonio Valencia, Marcos Rojo, Ander Herrera, Jesse Lingard and Anthony Martial all come in.
Wayne Rooney is on the bench.
Man Utd XI: De Gea, Valencia, Bailly, Smalling, Rojo, Herrera, Pogba, Lingard, Mata, Martial, Ibrahimovic.
Southampton have had two weeks to rest for this game and name the same team that beat Sunderland 4-0 a fortnight ago.
Potential debutant Martin Caceres is on the bench.
Southampton XI: Forster, Soares, Yoshida, Stephens, Bertrand, Romeu, Davis, Ward-Prowse, Tadic, Redmond, Gabbiadini.
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